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- $Unique_ID{BRK00999}
- $Pretitle{}
- $Title{What is Non-Hodgkins Lymphoma?}
- $Subject{lymphoma non-Hodgkins diagnosis Blood Forming NHL T cells cell thymus
- B bone marrow viral infection infections immunity immune system lymphoid
- hereditary genetic inherited AIDS enlarged lymph glands neck groin Weight loss
- fever night sweats weakness biopsy X-rays CT scans chemotherapy radiation
- therapy cancer cancers cancerous carcinoma neoplasm neoplasms remission
- monoclonal antibodies lymphokines interferons marrows laparotomy laparotomies}
- $Volume{U-22}
- $Log{
- AIDS Weakens the Immune System*0001003.scf
- Aspiration Biopsy*0001905.scf
- Location and Function of the Endocrine Glands*0002901.scf
- The Thymus*0002908.scf
- Immune Cell Production Sites I*0004501.scf
- Immune Cell Production Sites II*0004502.scf}
-
- Copyright (c) 1991-92,1993 Tribune Media Services, Inc.
-
-
- What is Non-Hodgkins Lymphoma?
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-
- QUESTION: I read your columns regularly, and now desire some information for
- myself. I have Non-Hodgkins Lymphoma. Maybe someday you can discuss this
- disease in your column. What is it, medications and cures?
-
- ------------------------------------------------------------------------------
-
- ANSWER: Well let's make "someday" . . . today. Non-Hodgkins Lymphomas (NHL)
- are a group of diseases that affect the lymphoid cells, causing growths that
- spread throughout the body. Hodgkin's Disease arises in a class of cells
- from the monocyte-histocyte series and is diagnosed by the presence
- of large cells with many nuclei (Reed-Sternberg cells). NHL springs from T
- cells (thymus derived) or B cells (bone marrow derived). NDL, with 7000
- to 8000 new cases diagnosed each year in the United States, is much more
- common than Hodgkin's, which accounts for 5000 to 6000 new cases each
- year. It strikes all age groups and is thought to be caused by viral
- infection. Another risk factor that is present in many is an impaired
- immunity system, either inherited or acquired as in AIDS. Most of the
- lymphomas seen in AIDS patients are of the B cell type. While symptoms may
- vary from patient to patient, enlarged lymph glands in the neck or groin are
- common. Weight loss, fever, night sweats and weakness indicates that the
- disease has spread throughout the body. A positive diagnosis depends upon
- obtaining a tissue specimen (biopsy) and examining the cells under the
- microscope. This also allows the pathologist to classify the state of
- progression of the disease and its specific cell type, which are important
- considerations in planning the therapy and treatment. Lymphomas may also be
- classified according to their cell types by using antibodies that can
- recognize and tell T cells from B cells. Various types of X-rays, including
- CT scans, are used to establish the extent of the disease, and rarely
- exploratory surgery (laparotomy) is needed to determine the spread of the
- tumors to spleen and abdominal lymph nodes. This process is known as
- Classification and Staging. Once the nature of the disease has been
- determined, the treatment can consist of one of more drugs (chemotherapy) with
- or without the use of radiation therapy. Modern cancer therapy has achieved
- its greatest results in the fields of leukemia and lymphoma, and there is a
- wide range of medications available that have been shown to be effective in
- these conditions. Some of these are cyclophosphamide, vincristine,
- prednisone, adriamycin and others used in combinations with strange names like
- CHOP and MOPP. Complete remission may be seen in from 60 to 80 percent of
- patients, cures can run to 50 percent depending upon the state of the disease
- at initial treatment. Because of the nature of the disease, these figures may
- only be considered as generalizations, and your case may differ. There is
- even more hope on the horizon with a wide range of new treatments already
- being investigated, or to begin soon. Being considered are monoclonal
- antibodies, lymphokines, interferons and growth factors. With improved
- techniques developing in bone marrow preservation, intensive treatment
- programs that replace bone marrow after high dose chemotherapy is under
- investigation for selected patients who do not respond to standard treatment
- programs. The marrow can be obtained from the patient before treatment or
- from a matched donor such as a brother or sister. With this much already
- accomplished, and all the new prospects on the horizons, it is not
- unreasonable to provide you with a positive report rather than a gloomy
- outlook.
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- ----------------
-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
-
-